At age 15 she landed a role in the daytime soap “The Edge of Night,” playing aspiring dancer Jody Travis. Lori later turned down a part that made Brooke Shields famous, the role of Emmeline in the 1980 movie “The Blue Lagoon.”
After “Full House,” Lori guest-starred in numerous sitcoms, including “The Drew Carey Show,” “Seinfeld,” and “Spin City.”
In 2004, she created the short-lived series “Summerland” for the WB network. Lori also produced and starred in the show as Ava Gregory, a thirty-something fashion designer raising her niece and nephews after their parents were killed in an accident.
"I was thinking about a friend of mine who is single -- she never had any children -- and works in the world of fashion,” Lori said. “She could handle herself in any situation except when you put her in a room full of children. That's what made me think of the whole concept -- what could I do not playing the mom. And I thought 'Maybe I could play the aunt.'"
For three seasons (2008-2011) Lori was a regular in “90210,” playing Debbie Wilson, an ex-Olympian who relocated to Beverly Hills with her family. She left the show after the producers decided to focus more on the younger castmates.